PROMOTED: Advances in Downstream Analysis for BioProcessing

Raman spectroscopy has been used increasingly for Process Analytical Technology (PAT) applications in the bioprocessing realm over the past decade. Most applications have been in the upstream arena for processes with mammalian cells, monitoring critical quality attributes such as glucose and lactate. However, Raman is now receiving increased attention in the downstream realm for protein purification. The interest comes from the fact that Raman can be used to monitor proteins eluting from a separation column, allowing for specific molecular information to be gathered. Such information allows discrimination of protein species and can facilitate the detection and quantitative analysis of critical molecular entities such as aggregates and charge-separated species. In this presentation, Kemper will explore the potential of Raman to be used for various tasks that enhance the control of downstream processing.

About the presenter
Mark Kemper is associate director of business development for Tornado Spectral Systems, a Bruker Company. His undergraduate and graduate degrees are in chemistry from the University of Dayton and the University of Minnesota, respectively. Kemper worked in the pharmaceutical industry for nine years as an analytical chemist before moving to the instrumentation industry, where he has worked for the past 30 years. During this time, he has mainly been involved with Raman, near infrared, FT-IR, terahertz and NMR technologies