Swept-Source Raman Provides Large-Scale Real-Time Monitoring

This presentation focuses on the pressing necessity for real-time chemical sensing in continuous pharmaceutical production and large-scale bioprocessing. Despite many advancements, current measurement techniques lack automation and provide delayed data. Continuous real-time monitoring can enhance product quality and reduce costs but scalability, both in terms of expense and sensor quantity, is imperative.

To address these challenges, Persits proposes a pragmatic solution: a utility service model using Swept Source Raman Spectroscopy (SSRS). The core of this model is the SSRS fiber probe, enabling Raman spectra measurement with minimal laser power yet equivalent sensitivity to benchtop systems. Leveraging existing optical fiber infrastructure, the expansion of SSRS into a large-scale sensor network, using a single shared laser source is demonstrated.

A demonstration of the network's performance is given by monitoring metabolites in mammalian cell cultures and additionally with measurements of hydroponic systems and environmental water samples, demonstrating new and exciting avenues for this novel chemical sensing architecture.

About the presenter
Nili Persits, Ph.D., is the founder and CEO of Dottir Labs, a company dedicated to advancing sensor technology for large-scale pharmaceutical production and bioprocesses. With a doctorate in electrical engineering and computer science from Massachusetts Institute of Technology and extensive industry experience in sensor development, Persits focuses on enhancing the efficiency, precision, and safety of biomanufacturing processes.

As a recipient of the prestigious Activate Fellowship, she is also expanding Dottir Labs' innovative solutions to tackle critical challenges in environmental and water monitoring. Driven by a commitment to harnessing technology in support of the environment and human health, Persits leads efforts to create sustainable, impactful solutions that benefit both industry and society.