Non-Computational High-Plex Imaging: Expanding Multiplexing Capabilities in Spatial Biology

Spatial biology is driving demand for higher-plex fluorescence imaging as researchers seek to measure more biomarkers within limited tissue samples while preserving spatial context. However, increased assay complexity can add pressure to acquisition speed, spectral separation, data processing, and workflow reproducibility.

This webinar explores practical approaches to non-computational high-plex imaging, including optical strategies for separating fluorophores, hardware considerations for automated filter changing, illumination and detection, and the trade-offs involved in scaling multiplexed fluorescence workflows.

Attendees will gain insight into the challenges shaping spatial biology instrumentation and how integrated optical and automation choices can support faster, more reliable, and easier-to-implement high-plex imaging workflows.

About the presenter
Simon Bush is product manager at Prior Scientific Instruments Ltd. He completed a master’s degree researching plant cell biology at Durham University and has spent a decade in the microscopy field in a variety of technical and commercial roles.

He has experience of a very broad spectrum of microscopy applications and systems, including high-end life science imaging with super-resolution microscopes, industrial inspection and image analysis with artificial intelligence. At Prior Scientific, he is responsible for overseeing the development of new microscopy automation products, customized microscopes and OEM imaging systems.