KEYNOTE: Advancing Therapeutic Drug Monitoring Through Raman Spectroscopy

Therapeutic drug monitoring is essential for optimizing pharmacotherapy, particularly for antibiotics with narrow therapeutic windows. Raman spectroscopy is a powerful method to advance this monitoring by utilizing a broad portfolio of Raman spectroscopic techniques, including deep ultraviolet resonance Raman spectroscopy (DUV-RRS), surface-enhanced Raman spectroscopy (SERS), and fiber-enhanced Raman spectroscopy (FERS). These methods enable rapid, label-free, and sensitive detection of drug concentrations in complex biological matrices.

The presentation will show that DUV-RRS combined with partial least squares regression accurately simulated the pharmacokinetics of levofloxacin, demonstrating its potential for real-time therapeutic drug monitoring applications. SERS can be employed for the detection of ceftriaxone in blood plasma, achieving high sensitivity and specificity. FERS has facilitated the in-situ monitoring of ciprofloxacin levels, underscoring its clinical applicability. Additionally, the impact of sample preparation on the accuracy of therapeutic drug monitoring is highlighted, emphasizing the need for standardized protocols. Collectively, these advancements underscore the potential of Raman-based spectroscopic techniques in drug monitoring, offering pathways toward personalized medicine and improved therapeutic outcomes.

About the presenter
Jürgen Popp, Ph.D., studied chemistry at the University of Erlangen-Nuremburg and the University of Würzburg in Germany. After finishing his doctorate in chemistry, he joined Yale University for postdoctoral work. He subsequently returned to the University of Würzburg, where he finished his habilitation in 2002. Since 2002, Popp has held a chair for physical chemistry at the Friedrich-Schiller University Jena in Germany. Since 2006, he has also been the scientific director of the Leibniz Institute of Photonic Technology in Jena.

Popp is a world-leading expert in biophotonics and optical health technology research, covering the complete range from basic photonics research to translation into clinically applicable methods. He has published more than 960 journal papers, has been named as an inventor on 12 patents, and has given more than 200 invited talks on national and international conferences, among them more than 50 were keynote/plenary lectures. In addition, he has organized numerous conferences and workshops, such as the world’s largest conference on Raman spectroscopy, ICORS, in 2014. He is editor-in-chief of the Journal of Biophotonics. Furthermore, he is a leading partner in various national and international projects in cooperation with academic, clinical, and industrial partners, and he has raised more than €50 million ($50 million) in third-party funding. He has been frequently asked to be a contact person for media and politics.

In 2012, he received an honorary doctoral degree from Babes-Bolyai University in Cluj-Napoca, Romania. Popp is the recipient of the 2013 Robert Kellner Lecture Award, and in 2016 he received the prestigious Pittsburgh Spectroscopy Award. Also in 2016, he was elected to the American Institute for Medical and Biological Engineering (AIMBE) College of Fellows. In 2018, Popp was awarded the renowned Ioannes Marcus Marci Medal of the Czech Society for Mass Spectrometry, he won the third prize of the Berthold Leibinger Innovationspreis, and he received the Kaiser-Friedrich-Forschungspreis. In 2019, he was awarded the Ralf-Dahrendorf-Preis für den Europäischen Forschungsraum, and in 2020 he became an Optica senior fellow. In 2021, he became a Fellow of the Royal Society of Chemistry (FRSC).